Injectable facial treatments Face biostimulators

Biostimulators are one of the most interesting categories of treatments in aesthetic medicine, as they aim to naturally activate the skin rather than simply “filling” wrinkles. They are injectable substances that stimulate skin cells (primarily fibroblasts) to produce collagen, elastin, and hyaluronic acid. Instead of acting as fillers, they function as activators of tissue repair and renewal.

Main types of biostimulators

• Poly-L-Lactic Acid (PLLA) → Gradually stimulates collagen production, providing long-lasting results (e.g., Sculptra, Lanluma).

• Poly-Caprolactone (PCL) → Addresses wrinkles and skin laxity immediately (e.g., Ellansé).

• Calcium Hydroxylapatite (CaHA) → Provides mild immediate volume and stimulates collagen production (e.g., Radiesse, HarmoniCa).

• Polynucleotides (PN / PN-HPT) → Nucleotides that help repair DNA and improve skin texture, hydration, and elasticity.

• Amino acids + vitamins (mesotherapy boosters) → Provide essential building blocks for metabolism and collagen synthesis.