Regenerative Medicine Nucleotides
Nucleotides are the building blocks of DNA and RNA and play a vital role in cellular health and renewal. They are essential for the proper function of every cell because:
• Nucleotides (e.g., ATP, GTP, UTP, CTP) are the units that form DNA and RNA—the carriers of genetic information—thus their role is primarily structural and genetic.
• ATP (adenosine triphosphate) is the main energy currency of cells. Glucose is broken down (through glycolysis, the Krebs cycle, and oxidative phosphorylation) and stores its energy in ATP.
• However, some nucleotides also have regulatory and energetic roles:
- ATP provides cellular energy.
- GTP is involved in signal transduction and protein synthesis.
- NAD⁺/NADH and FAD/FADH₂ (coenzymes derived from nucleotides) play a key role in electron transport.
Photo gallery / before & after
Photo gallery / before & after
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How do nucleotides contribute to anti-aging?
In anti-aging medicine, their action focuses on supporting cellular repair and tissue regeneration. Specifically, in the skin:
• They enhance the synthesis of new cells, promoting epidermal renewal.
• They help repair DNA damage caused by oxidative stress and UV radiation.
• They stimulate collagen and elastin production, reducing wrinkles and skin laxity.
• Nucleotides act as “fuel” for cells, improving their energy efficiency and resilience against aging.
As a result, they strengthen tissue regeneration, improve skin health, and support a long-term youthful appearance. -
Where do the nucleotides used in aesthetic medicine come from?
These nucleotides originate mainly from biotechnological or natural sources, depending on the product and manufacturer:
1. Biotechnological origin (synthetic or biosynthetic nucleotides):
- Most nucleotides are produced in the laboratory through biotechnology, using microorganisms such as E. coli or Saccharomyces cerevisiae.
- Through fermentation and purification processes, high-purity nucleic acids or polydeoxyribonucleotides (PDRN) are obtained.
2. Natural origin (mainly PDRN):
- The well-known PDRN (Polydeoxyribonucleotides) are extracted from salmon or trout DNA.
- This DNA undergoes purification and sterilization to ensure biocompatibility and safety for human use.
- This form is very popular in rejuvenation, healing, and anti-aging treatments due to its natural similarity to human DNA.
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Can nucleotides cause allergic reactions?
Substances containing nucleotides or polydeoxyribonucleotides (PDRN) are considered safe, with a very low risk of allergic reaction. However, as with any biological or injectable product, hypersensitivity cannot be entirely excluded. People with a history of fish or seafood allergies should inform their doctor, as some PDRN are derived from salmon DNA. If there is concern, a test microinjection (patch test) can be performed, or a fully synthetic, non-animal-derived formulation can be chosen.
